Scientific Bioprocessing, Inc. (SBI) is a leading provider of cell culture and bioprocessing optical sensors, instruments and systems for biotech, biopharma and the rapidly growing field of personalized medicine. SBI offers a suite of technologies and products that increase lab process efficiencies, enhance experiment repeatability, and consistently create ideal cell culture conditions that align with experiment design parameters.
SBI’s optical sensors and instruments are designed to make a bioprocessing engineer’s work easier, replacing time spent pushing liquids with time for creativity, discovery, and innovation.
“SBI’s mission is to empower our customers to accelerate the discovery of safe, effective, and affordable solutions in the biotech industry. Our optical sensors can be installed in the smallest scale, early development vessels all the way through clinical trials and downstream manufacturing post-approval. We believe we can deliver the instrumentation and sampling that is required to wring huge inefficiencies out of the development process,”
stated by SBI’s President John Moore.
Being able to monitor pH, dissolved oxygen (DO) and other key factors in real time from the smallest form factor all the way up to the largest bioreactor is a gamechanger for the cell culture and bioprocessing field. Using SBI’s optical sensors and desktop platforms empowers media and cell culture environment adjustments in the moment, protecting your run’s viability without agitating it with invasive, expensive electrochemical probes.
Optical sensors combined with closed-loop reporting systems are the future of bioprocessing. Making the transition to this future requires a willingness to move away from traditional, entrenched conventional wisdom, which can be daunting, but it doesn’t have to be.
That’s why SBI created its ID Developer’s Kit — to make this transition easier by providing bioprocessing engineers and cell culture labs with a single, easy-to-integrate, plug and play sensing system that is highly customizable to any lab’s unique processes and needs. The ID Developer’s Kit is part of SBI’s suite of Intelligent, Dynamic (ID) products and it provides everything a lab needs for real-time, non-invasive monitoring in one Kit.
The ID Developer’s Kit includes:
- Sensor pH
- Sensor DO
- Data Hub
“Science is all about finding a better way. We have found a better way. When technology advances, sometimes no one wants to be a first adopter,” stated Jake Boy, Senior Application Scientist at SBI. “Optical sensors are a really cool technology that allows you to do sensing where you couldn’t before, like in microfluidics for example. We want to spark the creative imagination. We created the Developer’s Kit to help get people’s feet wet with our system. The Kit gives you everything you need to get started.”
The ID Developer’s Kit is well-suited for a wide range of custom microbial and mammalian cell culture systems. The Sensor pH and Sensor DO can be as small as 3mm in diameter to fit even the smallest culture systems. Once the easy setup is complete and the Data Hub software is loaded on to your laptop, real-time data will pour in via the Kit’s converter. The optical pH and DO sensors included in the basic package provide bioprocessing engineers with 45 days of continual monitoring capability and several months of intermittent monitoring with a shelf life of one year, all with a two year warranty.
Along with the ID Developer’s Kit, bioprocessing engineers and lab team members receive support from SBI’s sensing system experts to customize the kit to their unique processes and experiments. Because the system is so user friendly, technical support is rarely too involved but is readily available to SBI’s customers.
Boy, who handles customer support for SBI among his other duties, stated, “I’ve had numerous video calls about how to use the sensors and the software with clients. Normally, we’d do this in person. The ID Developer’s Kit is extremely easy to use but it’s really new and not like anything else. Once you see it work once, though, our customers get it.”
“Customers can call me directly for assistance. If there is any issue, I will walk them through it and then I bring that feedback back to our team so we can continually improve and perfect our process and performance,” shared Boy.
SBI’s sensors and the ID Developer’s Kit offer versatility not provided by electrochemical probes; they also generate real-time data feedback that can’t be delivered by offline sensing. SBI’s optical sensors, which are very small, can be put in places that electrochemical probes simply can’t reach. Where an electrode can only sense at its tip, optical sensors can be placed anywhere in a culture vessel.
“Optical sensors are very inexpensive when compared to electrochemical sensors. They are also minimally invasive, essentially becoming a part of the culture vessel, which completely mitigates the risk for contamination,” stated Boy. “These sensors are also single-use, which cuts down on labor; once you’re done you just throw the sensors away and that eliminates the need to sterilize before your next run.”
“Our sensors also don’t require calibration, they don’t drift, are extremely stable and they provide extremely fast, real-time response times that allow detection of changes as they occur. On the other hand, electrochemical probes have to be recalibrated and that can take hours or even an entire day to complete, which can delay experiments.”
“In all of these ways, our sensors and ID Developer’s Kit are a vast improvement over what’s traditionally been used in cell culture and bioprocessing,” he added.
SBI’s cutting-edge optical sensors and desktop production systems provide bioprocessing engineers real-time data on how cells are doing so they can identify successful and problematic cultures quickly and make any necessary adjustments earlier in the process. Whether a lab is developing cell-based therapies, discovering new drugs, or engineering tissues and organs, SBI’s optical sensors are easy to deploy and augment cell culture effectiveness, repeatability and regulatory compliance.